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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remainHospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by Kidney

Keywords： acute kidney injury     risk factors     prognosis    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: We previously generated knockout mice and showed that Rdh13 deficiency causes severe acute retinalRdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injuryfunctions under regular culture, the mice displayed an attenuated response to CCl -induced liver injuryThis result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract: value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidneyinjury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectivelyA total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU groupADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients.

Keywords： diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage kidneyinjury    

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Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 307-318 doi: 10.1007/s11684-017-0547-2

Abstract:

Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by itsconstituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injuryPretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibitedthe cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury.neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury

Keywords： acute ischemic stroke     Ginkgo bilobaextract     Ginkgolide B     network model     neuroprotection    

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Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetic kidneyEpidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords： diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

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Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 80-85 doi: 10.1007/s11684-011-0115-0

Abstract: This study reports our experience in kidney transplantation in highly sensitized patients.Of 14 patients, 10 showed good graft functions without acute rejection (AR) episodes.Acute cellular rejection in two patients was reversed by methylprednisolone.desensitization using PP/IVIG with or without rituximab increases the likelihood of successful live-donor kidney

Keywords： Kidney transplantation     desensitization    

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Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 389-393 doi: 10.1007/s11684-014-0362-y

Abstract:

Studies conducted by our group on the mechanism of “kidney governing bones” theory in” Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms” Kidney deficiency refers to a deficiency in only one or more units of the kidney system and notAlthough both classified as kidney-reinforcing agents, the former can resolve failure of the “kidney;kidney governing bones” remains complicated and unresolved.

Keywords： kidney governing bones     kidney deficiency     marrow     osteoporosis     neuroendocrine-immune network     osteoclast    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: corresponding tumors is decreased while others remain as valuable as they are in patients with normal kidneyIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseasedecreased while serum AFP, CA, CA, PSA and fPSA were as valuable as they were in patients with normal kidney

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendeddrainage of bile and endoscopic stenting are the mainstays of treatment of bile leak because they convert acutebile duct injury into a controlled external biliary fistula.

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigatedendogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidneyinjury in DKD.

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 887-902 doi: 10.1007/s11684-021-0879-9

Abstract: Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear.the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury

Keywords： microRNAs     monocarboxylate transporter 1     motor training     subarachnoid hemorrhage     white matter injury    

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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 378-385 doi: 10.1007/s11684-017-0541-8

Abstract: purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney

Keywords： chronic kidney disease     microRNA     mineral bone disorder     uremia    

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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 197-205 doi: 10.15302/J-FASE-2018245

Abstract: Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative

Keywords： cerebral ischemia     GABA     neuroprotection     leonurine     SOD    

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Progress and perspectives of neural tissue engineering

Xiaosong Gu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 401-411 doi: 10.1007/s11684-015-0415-x

Abstract:

Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.

Keywords： nerve injury     tissue engineering     nerve grafts    

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Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice

WANG Lin, LIU Yalan, XU Jianbo, TIAN Yuan, WU Heshui

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 182-185 doi: 10.1007/s11684-008-0034-x

Abstract: evidence for the effective prevention and treatment of lipopolysaccharide (LPS)-induced hepatocyte injuryNAC has protective effects in hepatocytes of neonatal mice against LPS-induced injury as shown by the
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Title Author Date Type Operation

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Journal Article

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Journal Article

Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Journal Article

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Journal Article

Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Journal Article

Progress and perspectives of neural tissue engineering

Xiaosong Gu

Journal Article

Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice

WANG Lin, LIU Yalan, XU Jianbo, TIAN Yuan, WU Heshui

Journal Article